venofer dosing calculator

Methods. HOW TO USE: This medication is given by injection into a vein as directed by your doctor. Copyright 2021 GlobalRPH - Web Development by, Calculation of the Total Iron Deficit Alternative equation. This site complies with the HONcode standard for trust- worthy health information: verify here. Venofer (Iron Sucrose Injection) may treat, side effects, dosage, drug interactions, warnings, patient labeling, reviews, and related medications including drug comparison and health resources. Applies only to oral form of both agents. Access your plan list on any device mobile or desktop. Introduction Uses Dosage Warnings Interactions Stability Introduction Hematinic agent; a polynuclear iron (III)-hydroxide sucrose complex. Dosing and Infusion Rates - PRIVIGEN sodium sulfate/potassium sulfate/magnesium sulfate decreases levels of iron sucrose by inhibition of GI absorption. Can't find what you need? Applies only to oral form of both agents. Applies only to oral form of both agents. Either increases effects of the other by pharmacodynamic synergism. If no signs or symptoms of anaphylactic-type reactions follow the test dose, administer the full therapeutic INFeD dose. This information does not assure that this product is safe, effective, or appropriate for you. Prior to and at regular intervals during parenteral iron therapy, evaluate serum iron, hemoglobin, and hematocrit. Consult your doctor before breast-feeding. Ferumoxytol [ Feraheme ] Elemental iron: 510 mg/17 mL (17 mL) 30 mg/mL [package insert] - Boxed warning REVIEW INSERT. Applies only to oral form of both agents. Oral and parenteral products - see background option for oral products. Recommended Treatment Regimen Using IV Iron Sucrose for Initial Repletion in Children With Iron Deficiency Anemia. Fulminant symptoms may include general paleness, confusion or episodes of passing out. Compare formulary status to other drugs in the same class. commonly, these are generic drugs. In less advanced cases of iron deficiency, increases in dietary intake of iron may be sufficient. Available for Android and iOS devices. We have found the lower dose to be better tolerated in the second half of gestation. Option 2: 200 mg in NS 100 mL administered over 20-30 minutes; may repeat every other day to Written by ASHP. Maximum single dose of iron sucrose to be given at a time in Non-dialysis CKD patients is 500 mg but with limited experience. Applies only to oral form of both agents. Do not dilute to concentrations below 1 mg/mL [see How Supplied/Storage and Handling (16.2).] Modify Therapy/Monitor Closely. Where: Medicine concentration Amount of active substance per a given volume of your drug. Modify Therapy/Monitor Closely. Monitor Closely (1)dexlansoprazole will decrease the level or effect of iron sucrose by increasing gastric pH. *Repeat dose if iron deficiency anemia reoccurs. Manufacturer advises for slow intravenous injection ( Venofer ), give undiluted at a rate of 1 mL/minute; do not exceed 10 mL (200 mg iron) per injection. Serious - Use Alternative (1)iron sucrose decreases levels of levofloxacin by inhibition of GI absorption. Read our. Use Caution/Monitor. 2010; 193(9):525-32. Use Caution/Monitor. Treatment of iron deficiency anemia in adults - UpToDate Maximum infusion rate: 100 mg / hour (Slow infusion rate of iron sucrose is recommended to minimize adverse reactions, especially hypotension) Frequency of infusion: Dose may be repeated up to 3 times weekly to provide total iron dose. 2 Protocol for Intravenous iron sucrose - Venofer 2.1 Dosage The total cumulative dose of Venofer should be calculated using the table below. Applies only to oral form of both agents. 2 DOSAGE & ADMINISTRATION Venofer must only be administered intravenously either by slow injection or by infusion. Minor (2)calcium gluconate decreases levels of iron sucrose by inhibition of GI absorption. MDCalc loves calculator creators researchers who, through intelligent and often complex methods, discover tools that describe scientific facts that can then be applied in practice. Dosage Calculator - [100% Free] - Calculators.io Iron supplements, regardless of their way of administration, are used to replete body stores and to correct anemia. Applies only to oral form of both agents. Avoid or Use Alternate Drug. Inspect parenteral drug products visually for the absence of particulate matter and discoloration prior to administration. Hemoglobin iron deficit = 60 x (14 - 8) x (2.145) = 772 mg iron. 2010niferex-hytinic-polysaccharide-iron-342160Drugs, You are being redirected to Intravenous iron-dextran: therapeutic and experimental possibilities. 1996 Aug;11(4):139-46. Applies only to oral form of both agents. Monitor Closely (1)sodium bicarbonate will decrease the level or effect of iron sucrose by increasing gastric pH. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Minor/Significance Unknown. 2015: 763576. Interaction only with oral iron administration. Monitor Closely (1)sodium sulfate/?magnesium sulfate/potassium chloride decreases levels of iron sucrose by inhibition of GI absorption. sodium bicarbonate will decrease the level or effect of iron sucrose by increasing gastric pH. Applies only to oral form of both agents. Iron stores 500 mg for body weight greater than or equal to 35 kg (77 lbs) and 15 mg/kg for body weight less than 35 kg. (1970) Intravenous iron-dextran: therapeutic and experimental possibilities. Studies in monkeys showed concurrent use with calcium, aluminum, or iron caused significantly decreased plasma levels. Controlled studies in pregnant women show no evidence of fetal risk. trientine, iron sucrose. The dosage of Venofer is expressed in mg of elemental iron. with NDD-CKD or PDD-CKD who are on erythropoietin therapy for iron maintenance treatment, Hemodialysis-dependent chronic kidney disease (HDD-CKD)*, Non-dialysis-dependent chronic kidney disease (NDD-CKD), Peritoneal-dialysis-dependent chronic kidney disease (PDD-CKD), At a dose of 0.5 mg/kg, not to exceed 100 mg per dose, Given undiluted by slow intravenous injection over 5 minutes or diluted in 0.9% NaCl at concentrations of 1 to 2 mg/mL and administered over 5 to 60 minutes, An increase in Hb concentration or a decrease in ESA dose is desired and. Minor/Significance Unknown. Last updated 28/06/2018 Enter values here and press 'Calculate'. The two formulas used are presented below: Iron deficit in mg = Weight in kg x (14 - Hb in g/dL) x 2.145 Volume of product required in mL = Iron deficit in mg / C in mg/mL Where C is the concentration of the iron product: 50 mg/mL for Iron dextran; 20 mg/mL for Iron sucrose; 5 mg/mL for Ferric gluconate. Applies only to oral form of both agents. Uses for Iron Sucrose Am J Kid Dis 2001; 38 988991. Challenges in the treatment of iron deficiency include finding and addressing the underlying cause and the selection of an iron replacement product that meets the needs of the patient. Administer on 5 different occasions over a 14 day period. Applies only to oral form of both agents. May increase risk of hypotension. Administer iron products at least 2 hr before and no less than 6 hr after each dose to avoid chelation with magnesium. . Serious - Use Alternative (1)iron sucrose decreases levels of eltrombopag by inhibition of GI absorption. 1970; 100(7):301-3. Administer ciprofloxacin at least 2 hours before or 6 hours after using these products. J Lab Clin Med; 111(5):566-70. Anemia of chronic disease (ACD), Calculation of the Total Iron Deficit equation appears in Cosmofer PI, Calculation of the Total Iron Deficit Alternative equation, Iron Dextran Dosing Calculator (iron deficit), HONcode standard for trust- worthy health, Pediatric Oncology: Diagnosis And Prognosis Communication, Pharmacosmos A/S, CosmoFer low molecular weight (Mw) iron dextran. For males: LBW = 50 kg + 2.3 kg for each inch of patients height over 5 feet For females: LBW = 45.5 kg + 2.3 kg for each inch of patients height over 5 feet. elemental iron (mg/ml) in the product being used: Where C= Drug class: Iron products. iron sucrose decreases levels of manganese by inhibition of GI absorption. 1. Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature. Ganzoni AM. This site complies with the HONcode standard for trust- worthy health information: verify here. Avoid or Use Alternate Drug. gymnema decreases levels of iron sucrose by inhibition of GI absorption. Applies only to oral form of both agents. Applies only to oral form of both agents. Monitor Closely (1)didanosine will decrease the level or effect of iron sucrose by increasing gastric pH. Monitor Closely (1)iron sucrose decreases levels of penicillamine by inhibition of GI absorption. Applies only to oral form of both agents. 1) Ganzoni AM. Then enter the value of the Dosage and choose the unit of measurement from the drop-down menu. . Hemodialysis-dependent CKD: 100 mg elemental iron IV (injection or infusion over 2-5 min) per dialysis session not to exceed total cumulative dose of 1000 mg divided in 3 doses/week. commonly, these are "non-preferred" brand drugs or specialty Deferasirox chelates iron. PRECAUTIONS: Before using iron sucrose, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. PDF Iron Sucrose: Guidelines for Administration Document Type: Guideline -Hgb deficit (grams) = Hgb deficit (g/dL) x blood volume (dL) -Iron deficit (mg) = Hgb deficit (grams) x 3.3 (mg Fe/g Hgb) [Note: 3.3 x 0.65 = 2.145] -Volume of parenteral iron product req'd (mL) = [Iron deficit (mg)] / C(mg/mL) Final calculations: -Hgb iron deficit (mg) = weight (kg) x (14 - Hgb) x (2.145) -Volume of product required (mL) = [weight (kg)x (14 - Hgb) x (2.145)] / C Where C= concentration of elemental iron (mg/ml) in the product being used: Iron dextran: 50 mg/mL. DailyMed - VENOFER- iron sucrose injection, solution Use Caution/Monitor. Applies only to oral form of both agents. Use Caution/Monitor. Parenteral Iron Replacement For Iron Deficiency Anemia Calculator There are four fields that need to be completed: Weight body weight is used to establish iron deficit and is also taken into account when estimating the iron stores. Many people using this medication do not have serious side effects.Severe dizziness or fainting (hypotension) may occur while you are receiving IV iron. Parenteral Iron Replacement For Anemia Calculator - MDApp 1970;100(7):301303. IMPORTANT: HOW TO USE THIS INFORMATION: This is a summary and does NOT have all possible information about this product. 300-500 mg Iron Sucrose in NS 250 mL administered over three (3) hours; may repeat as needed in 3-7 days to reach 1 gm. INFeD is given undiluted at a slow gradual rate not to exceed 50 mg (1 mL) per minute. Clinical calculators for obstetrics and gynaecology - calculosaurus Patients diagnosed with iron deficiency are prescribed iron supplementation, either to replete body stores or to correct anemia. Auerbach M, Witt D, Toler W, Fierstein M, Lerner RG, Ballard H. Clinical use of the total dose intravenous infusion of iron dextran. This calculator will help pinpoint potential causes of anemia based on 1990 Feb;24(2):162-6. For males: LBW = 50 kg + 2.3 kg for each inch of patients height over 5 feet For females: LBW = 45.5 kg + 2.3 kg for each inch of patients height over 5 feet Administration: I. The recommendation is that most adults need a cumulative dose of elemental iron of at least 1 g. Iron replenishment can be done intravenously, either as total dose (example: iron-dextran or iron carboxymaltose) or as split dose (example: iron sucrose). Dosing for patients who weigh 50 kg or more For patients weighing 50 kg (110 lb) or more: Give Injectafer in two doses separated by at least 7 days. Minor/Significance Unknown. Venofer (iron sucrose injection, USP) For Intravenous Use Only INDICATION AND USAGE Venofer (iron sucrose injection, USP) is indicated for the treatment of iron deficiency anemia (IDA) in patients with chronic kidney disease (CKD). Ferric gluconate: 12.5 mg/mL Schrier SL, Mentzer WC, Landaw SA. The Ganzoni equation used by the iron deficiency calculator is the following: Total iron deficit (mg) = Weight in kg x (Target Hb - Actual Hb in g/dL) x 2.4 + Iron stores The recommendation is that most adults need a cumulative dose of elemental iron of at least 1 g. It is unlikely . Copyright(c) 2023 First Databank, Inc. The initial hemoglobin rise is more rapid with parenteral iron but on the long term (12 weeks), both therapies reach similar levels of hemoglobin. Use Caution/Monitor. Intravenous iron sucrose: establishing a safe dose - PubMed Most reactions associated with intravenous iron preparations occur within 30 minutes of the completion of the infusion. Applies only to oral form of both agents. PDF Iron dosing and administration in adults backgrounder Administer on 5 different occasions over a 14 day period. Avoid or Use Alternate Drug. Use Caution/Monitor. Included in the iron dextran package insert. 20 mg/mL for Iron sucrose; 5 mg/mL for Ferric gluconate. Reactions have occurred following the first dose or subsequent doses of Venofer. 2010;18(3). Last updated on Jun 1, 2022. Use Caution/Monitor. Applies only to oral form of both agents. A patients lean body weight (or actual body weight if less than lean body weight) should be utilized when determining dosage. Copyright 2021 GlobalRPH - Web Development by. Applies only to oral form of both agents. iron sucrose will decrease the level or effect of baloxavir marboxil by cation binding in GI tract. Have resuscitation equipment and personnel trained in the detection and treatment of anaphylactic-type reactions readily available during INFeD administration. LBW = Lean body weight in kg. Dosing Administration & Considerations . Minor/Significance Unknown. Applies only to oral form of both agents. Deferoxamine chelates iron. PDF PRODUCT MONOGRAPH - pdf.hres.ca Monitor Closely (1)rabeprazole will decrease the level or effect of iron sucrose by increasing gastric pH. Use Caution/Monitor. When administering as a slow intravenous push, give at the rate of approximately 100 mg (2 mL) per minute. iron sucrose decreases levels of methyldopa by inhibition of GI absorption. Due Date form Ultrasound Report. Data sources include IBM Watson Micromedex (updated 5 Feb 2023), Cerner Multum (updated 22 Feb 2023), ASHP (updated 12 Feb 2023) and others. Applies only to oral form of both agents. Adults and Children over 15 kg (33 lbs): Dose (mL) = 0.0442 (Desired Hb - Observed Hb) x LBW + (0.26 x LBW), Desired Hb = the target Hb in g/dl. Test Dose: Not required. Ferrlecit has been administered at sequential dialysis sessions by infusion or by slow intravenous injection during the dialysis session itself. Burns DL, Mascioli EA, Bistrian BR. Venofer must only be administered intravenously either by slow injection or by infusion. Hollands J, Foote E, Rodriguez A. 2. Applies only to oral form of both agents. Either decreases levels of the other by inhibition of GI absorption. Avoid or Use Alternate Drug. Iron deficiency anemia calculator (diagnosis), Iron deficiency anemia vs. Serious - Use Alternative (1)iron sucrose decreases levels of gemifloxacin by inhibition of GI absorption. iron sucrose decreases levels of moxifloxacin by inhibition of GI absorption. iron sucrose decreases levels of doxycycline by inhibition of GI absorption. Venofer (iron sucrose) 20 mg iron / ml, solution for injection or Minor/Significance Unknown. Applies only to oral form of both agents. Applies only to oral form of both agents. Dosage Calculator Iron Product. Use Caution/Monitor. Untreated IDA in pregnancy is associated with adverse maternal outcomes such as post-partum anemia. didanosine will decrease the level or effect of iron sucrose by increasing gastric pH. If dose exceeds 20mg/kg it should be rounded down to 20mg/kg OR administration of the total dose has to be split and given 7 days apart. Venofer (iron sucrose) dose calculator | Calculosaurus.com Clinical calculators for obstetrics and gynaecology VTE risk assessment Calculator menu Venofer dose calculator Iron sucrose Not what you were looking for? Applies only to oral form of both agents. iron sucrose decreases levels of tetracycline by inhibition of GI absorption. Use alternatives if available. Serious - Use Alternative (1)iron sucrose decreases levels of demeclocycline by inhibition of GI absorption. For iron maintenance treatment, administer Venofer, (2 years of age or older) with NDD-CKD or PDD-CKD who are on erythropoietin therapy for iron maintenance treatment. Applies only to oral form of both agents. Applies to didanosine chewable tablets and powder for oral solution; administer 2 hr before or several hours after didanosine oral solution or chewable tablet administration. Learn how to store and discard medical supplies safely. Fulminant symptoms include confusion, sensation of passing out, paleness. Coadministration of ciprofloxacin with multivalent cation-containing products may reduce the bioavailability of ciprofloxacin by 90%. Situation Analysis Market Size MAT Sales Cr LC MAT Share % MAT Gr % Total Pharma Market 9388.69 100 13.5 Iron Sucrose 11.18 93.81 37.65 Brand Company Saline MAT . 4. May increase risk of hypotension. If you miss a dose, ask your doctor or pharmacist right away for a new dosing schedule. By using this form you agree with the storage and handling of your data by this website. Serious - Use Alternative (1)iron sucrose decreases levels of tetracycline by inhibition of GI absorption. Mean Corpuscular Hemoglobin Concentration (MCHC) Calculator, Red Blood Cell (RBC) Indices Calculator, Iron Deficiency In Pregnancy Calculator. Comparable efficacy to that of IV iron sucrose. iron sucrose decreases levels of gemifloxacin by inhibition of GI absorption. Use Caution/Monitor. Each mL contains 20 mg of elemental iron. Applies only to oral form of both agents. Venofer may cause clinically significant hypotension. Studies in monkeys showed concurrent use with calcium, aluminum, or iron caused significantly decreased plasma levels. This website is intended for use by US healthcare professionals only. Most During all INFeD administrations, observe for signs or symptoms of anaphylactic-type reactions. USES: This medicine is used to treat "iron-poor" blood (anemia) in people with long-term kidney disease. 3) Auerbach M, Witt D, Toler W, Fierstein M, Lerner RG, Ballard H. (1988) Clinical use of the total dose intravenous infusion of iron dextran. Minor (2)calcium chloride decreases levels of iron sucrose by inhibition of GI absorption. Venofer is indicated for the treatment of iron deficiency anemia (IDA) in patients with chronic kidney disease (CKD). It is usually given slowly over 2 to 5 minutes or as directed by your doctor. NOTES: Lab and/or medical tests (such as complete blood count, ferritin, transferrin, total iron binding capacity-TIBC) should be done while you are using this medication. Applies only to oral form of both agents. Use Caution/Monitor. Serious hypersensitivity reactions, including anaphylactic-type reactions, some of which have been life-threatening and fatal, have been reported in patients receiving Venofer. Use Caution/Monitor. By entering this website, you acknowledge that you are a licensed healthcare professional practicing in the United States. Iron Sucrose - Injection - Alberta 2) Koch TA, Myers J, Goodnough LT. (2015) Intravenous Iron Therapy in Patients with Iron Deficiency Anemia: Dosing Considerations. Administer Venofer only intravenously by slow injection or by infusion. Avoid or Use Alternate Drug. Iron deficit - equation derivation: Assumptions: -Blood volume = 65 mL/kg -Hemoglobin conc target =14.0 g/dL -Deficits in body stores are ignored. Immune system disorders: Anaphylactic-type reactions, angioedema, Nervous system disorders: Convulsions, collapse, light-headedness, loss-of-consciousness, Respiratory, thoracic and mediastinal disorders: Bronchospasm, dyspnea, Musculoskeletal and connective tissue disorders: Back pain, swelling of the joints, General disorders and administration site conditions: Hyperhidrosis, Published studies on intravenous iron sucrose treatment after first trimester of pregnancy not shown adverse maternal or fetal outcomes; available reports of intravenous iron sucrose use in pregnant women during first trimester are insufficient to assess risk of major birth defects and miscarriage; iron deficiency anemia during pregnancy should be treated because there are risks to mother and fetus associated with untreated iron deficiency anemia (IDA) in pregnancy; risks to fetus associated with maternal severe hypersensitivity reactions, Severe adverse reactions including circulatory failure (severe hypotension, shock including in the context of anaphylactic reaction) may occur in pregnant women with parenteral iron products which may cause fetal bradycardia, especially during second and third trimester, Iron sucrose is present in human milk, and available published reports following exposure to 100-300 mg intravenous iron sucrose have not reported adverse reactions in breastfed infants; there are no data on effects on milk production, Developmental and health benefits of breastfeeding should be considered, along with mothers clinical need for treatment and any potential adverse effects on breastfed child from therapy or from underlying maternal condition. Jacobs P, Dommisse J. Anemia; 2015: 763576. The recommended dosage of iron sucrose for repletion of iron deficiency in patients undergoing hemodialysis is 5ml of iron sucrose (100mg of elemental iron) delivered intravenously during the dialysis session. rabeprazole will decrease the level or effect of iron sucrose by increasing gastric pH. Parenteral iron product is iron sucrose (C = 20 mg elemental iron/mL). In the text below the tool there is more information on how the iron deficit is calculated. This drug is available at a higher level co-pay. Human studies not conducted. For all products, slow initial infusion is prudent; the patient is observed closely for infusion reactions. May increase risk of hypotension. Volume of iron product required = 25 mL. Iron sucrose: 20 mg/mL. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. in the colostrum of 10 iron deficient breastfeeding women who were 2 to 3 days postpartum and received a single dose of 100 mg of intravenous iron . Serious - Use Alternative (1)iron sucrose decreases levels of ciprofloxacin by inhibition of GI absorption. Iron Sucrose - SlideShare David McAuley, Pharm.D. Use Caution/Monitor. however iron sucrose requires multiple small intermittent doses over days to weeks. Hemoglobin there are two fields for hemoglobin input, one for the target and another for actual value. Use Caution/Monitor. Below the form there are further instructions on how to use the calculator. This drug is available at a middle level co-pay. In this study and another study evaluating a single intravenous dose of iron sucrose containing 500-700 mg of iron in 26 anemic patients on erythropoietin therapy (23 female, 3 male; age range 16-60), approximately 5% of the iron was . There are physiological variation in iron reserves such as the decrease during menstruation period. lansoprazole will decrease the level or effect of iron sucrose by increasing gastric pH. Contact the applicable plan https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=abacb7fa-2fc2-471e-9200-944eeac8ca2a. Adult Patients: The most common adverse reactions (2%) include diarrhea, nausea, vomiting, headache, dizziness, hypotension, pruritus, pain in extremity, arthralgia, back pain, muscle cramp, injection site reactions, chest pain and peripheral edema. Bhowmik D, Modi G, Ray D, Gupta S, Agarwal SK, Tiwari SC, Dash SC. The above information is provided for general Iron metabolism needs to be balanced and bleeding, the major cause of iron deficiency (for instance in menstruation in females and chronic occult gastrointestinal bleeding) needs to be addressed. Iron Sucrose [ Venofer ] Elemental iron: 20 mg/mL (2.5 mL, 5 mL, 10 mL) Solution, Intravenous [preservative free]: [package insert] INDICATIONS: Venofer is an iron replacement product indicated for the treatment of iron deficiency anemia in patients with chronic kidney disease (CKD). Avoid or Use Alternate Drug. Nutrition. INDICATIONS AND USAGE: Intravenous or intramuscular injections of INFeD are indicated for treatment of patients with documented iron deficiency in whom oral administration is unsatisfactory or impossible.